COMPLETE ANDROGEN BLOCKADE SAFELY ALLOWS FOR DELAY OF CYTOTOXIC CHEMOTHERAPY IN CASTRATION REFRACTORY PROSTATE CANCER

PURPOSE: Complete androgen blockade (CAB) does not prolong overall survival (OS) in patients with castration refractory prostate cancer (CRPC).Although there is variable clinical benefit with second-line hormone manipulation, we do not know which patients might benefit the most.OBJECTIVES: To identify clinical predictors of benefit of complete andr

ABSTRACT Intervening proteins, or inteins, are mobile genetic elements that are translated within host polypeptides and removed at the protein level by splicing.In protein splicing, a self-mediated reaction removes the intein, leaving a peptide COLOSTRUM bond in place.While protein splicing can proceed in the absence of external cofactors, several